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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN2
All Species:
25.15
Human Site:
S470
Identified Species:
39.52
UniProt:
Q9H0D6
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0D6
NP_036387.2
950
108582
S470
E
M
R
M
Q
N
N
S
S
P
S
I
S
P
N
Chimpanzee
Pan troglodytes
XP_514546
950
108522
S470
E
M
R
M
Q
N
N
S
S
P
S
I
S
P
N
Rhesus Macaque
Macaca mulatta
XP_001094734
961
109718
S470
E
M
R
M
Q
N
N
S
S
P
S
I
S
P
N
Dog
Lupus familis
XP_534324
950
108331
S470
E
M
R
M
Q
N
N
S
S
P
S
I
S
P
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBR1
951
108669
S470
E
M
R
M
Q
R
N
S
S
P
S
I
S
P
N
Rat
Rattus norvegicus
NP_001102066
561
63850
R145
D
A
A
D
E
K
F
R
R
K
V
V
Q
S
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505862
950
108030
S470
E
M
R
M
Q
N
N
S
S
P
S
A
S
P
N
Chicken
Gallus gallus
Q5ZIP4
949
108524
N469
M
R
M
H
D
R
Q
N
S
T
M
S
S
P
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM71
908
103942
K458
Q
R
S
V
G
N
Y
K
E
E
A
A
A
L
R
Honey Bee
Apis mellifera
XP_392371
860
99367
P429
L
G
I
S
N
N
K
P
K
W
I
P
T
G
Q
Nematode Worm
Caenorhab. elegans
Q9U299
975
110109
A490
T
N
D
A
N
E
T
A
A
A
N
L
K
A
L
Sea Urchin
Strong. purpuratus
XP_795068
1073
120270
A461
R
T
S
S
R
D
N
A
N
Q
S
A
A
D
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FQ03
1020
116807
P480
Q
K
V
R
R
L
S
P
G
S
S
V
G
A
A
Baker's Yeast
Sacchar. cerevisiae
Q02792
1006
115915
S487
N
E
L
M
K
D
I
S
K
E
E
I
D
D
A
Red Bread Mold
Neurospora crassa
Q8WZX5
1072
118291
S512
S
M
M
A
Q
G
T
S
T
P
E
N
G
A
E
Conservation
Percent
Protein Identity:
100
99.7
97.6
98
N.A.
96
56.2
N.A.
91.1
82.9
N.A.
N.A.
N.A.
51.2
54
50.5
52.5
Protein Similarity:
100
99.8
98
99
N.A.
97
57.6
N.A.
95.4
90.5
N.A.
N.A.
N.A.
63.2
66.5
63.7
63.4
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
93.3
26.6
N.A.
N.A.
N.A.
6.6
6.6
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
20
N.A.
93.3
33.3
N.A.
N.A.
N.A.
33.3
13.3
26.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.6
40.5
40.8
Protein Similarity:
N.A.
N.A.
N.A.
58
57.4
56.1
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
33.3
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
14
0
0
0
14
7
7
7
20
14
20
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
7
7
7
14
0
0
0
0
0
0
7
14
0
% D
% Glu:
40
7
0
0
7
7
0
0
7
14
14
0
0
0
7
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
7
7
0
0
7
0
0
0
14
7
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
0
0
7
0
0
0
7
40
0
0
0
% I
% Lys:
0
7
0
0
7
7
7
7
14
7
0
0
7
0
0
% K
% Leu:
7
0
7
0
0
7
0
0
0
0
0
7
0
7
7
% L
% Met:
7
47
14
47
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
7
7
0
0
14
47
47
7
7
0
7
7
0
0
47
% N
% Pro:
0
0
0
0
0
0
0
14
0
47
0
7
0
47
0
% P
% Gln:
14
0
0
0
47
0
7
0
0
7
0
0
7
0
7
% Q
% Arg:
7
14
40
7
14
14
0
7
7
0
0
0
0
0
7
% R
% Ser:
7
0
14
14
0
0
7
54
47
7
54
7
47
7
0
% S
% Thr:
7
7
0
0
0
0
14
0
7
7
0
0
7
0
0
% T
% Val:
0
0
7
7
0
0
0
0
0
0
7
14
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _